Surface display of a manganese-binding domain enhances production and stress resistance in Bacillus subtilis spores
These findings demonstrated that surface-expressed manganese binding domain could modulate spore physiology, improving both production and resistance, and highlight the potential of surface-displayed proteins in spore-based biotechnological applications, particularly recombinant spore-based vaccines that combine immunogenic antigen presentation with enhanced structural robustness.
Authors
- Trang Thi Phuong Phan (ORCID: https://orcid.org/0000-0002-4255-0495)
- Tuom Thi Tinh Truong (ORCID: https://orcid.org/0000-0002-8454-3656)
- Hoang Duc Nguyen (ORCID: https://orcid.org/0000-0003-2437-3568)
- Nhi N. Y. Nguyen (ORCID: https://orcid.org/0000-0002-7922-0270)
- Dong Van Nguyen
Institutions
- Vietnam National University Ho Chi Minh City (VN)
- Ho Chi Minh City University of Science (VN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3389/fmicb.2025.1669207
- Primary Topic
- Bacterial Genetics and Biotechnology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Foundation for Science and Technology Development
- Tập đoàn Vingroup - Công ty CP
- Viet Nam National University Ho Chi Minh City
- Quỹ Đổi mới sáng tạo Vingroup