Persistent lymphocytopenia in convalescent patients with COVID-19: dysregulated B cell, CD4+ T cell, and treg compartments in 7–12% of moderate-severe cases
Approximately 7-12% of moderate-to-severe COVID-19 survivors displayed persistent lymphopenia affecting B cells, CD4<sup>+</sup> T cells, and Tregs at ~50 days post-symptom onset. These findings highlight distinct recovery trajectories and provide insights into Long COVID pathogenesis that may inform therapeutic strategies.
Authors
- Yongyu Wang (ORCID: https://orcid.org/0000-0002-6088-8887)
- Anyuan Wang (ORCID: https://orcid.org/0000-0002-8635-3952)
- Ming Li (ORCID: https://orcid.org/0000-0001-7049-8666)
- Chen Zhang (ORCID: https://orcid.org/0000-0002-9461-1755)
- Hao Hu (ORCID: https://orcid.org/0000-0003-1959-6740)
- Hui Jeong An
- Tongtong Yu
Institutions
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3389/fcimb.2025.1693743
- Citations
- 1
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Wenzhou Medical University
- National Natural Science Foundation of China