Thymoquinone and aerobic exercise mitigate HFpEF-induced cardiac injury via Apaf1/Cycs axis regulation
These findings demonstrate that TQ and aerobic exercise exert synergistic cardioprotective effects in HFpEF by attenuating oxidative stress, fibrosis, and apoptosis through inhibition of the Apaf1/Cycs apoptotic pathway. The results provide new insights into adjunctive therapeutic strategies for HFpEF management.
Authors
- Jin Yang (ORCID: https://orcid.org/0009-0001-6263-0695)
- Zuowei Pei (ORCID: https://orcid.org/0000-0002-1009-0025)
- Shan Gao (ORCID: https://orcid.org/0000-0003-0871-1694)
- Chang Liu (ORCID: https://orcid.org/0000-0001-8489-2605)
- Yanyan Pan (ORCID: https://orcid.org/0000-0002-8737-6101)
Institutions
- Dalian University of Technology (CN)
- Dalian Municipal Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3389/fphar.2025.1672570
- Primary Topic
- Nigella sativa pharmacological applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Dalian University of Technology