Prognostic genes related to mitochondrial dynamics and mitophagy in diffuse large B-cell lymphoma are identified and validated using an integrated analysis of bulk and single-cell RNA sequencing
<i>TCF7</i>, <i>CEBPA</i>, <i>BBC3</i>, <i>GALR3</i>, <i>BMP8B</i>, and <i>BAALC</i> were identified as novel lysosomal pathway-enriched prognostic genes in DLBCL. Our validated composite model demonstrated strong predictive power. These findings establish an association between high-risk disease and specific tumor microenvironment alterations (M0 macrophages), epitranscriptomic dysregulation (m6A), and therapeutic vulnerabilities, providing valuable insights for refining prognosis and advancing targeted therapies for DLBCL.
Authors
- Qiaoxian Lin
- Zhiyong Zeng (ORCID: https://orcid.org/0000-0003-0558-3906)
- Jinlong Huang (ORCID: https://orcid.org/0000-0002-4179-5001)
- Jizhen Wang
- Qingjiao Chen
- Guilan Lai
- Xiaolin Zhu
- Xiaoqiang Zheng (ORCID: https://orcid.org/0009-0006-0688-3758)
- Jun‐Fang Lin (ORCID: https://orcid.org/0000-0002-2981-5188)
- Junmin Chen (ORCID: https://orcid.org/0000-0001-6218-1677)
- Min Chen (ORCID: https://orcid.org/0000-0002-0093-9056)
- Jinfeng Dong
- Meihong Zheng
- Apeng Yang
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Community Health Center (US)
- Fuzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1686948
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00