PD-L1 regulates c-MET phosphorylation and contributes to MET-dependent resistance to osimertinib in EGFR-mutant NSCLC
In EGFR-mutant NSCLC, PD-L1 regulates c-MET phosphorylation and promotes MET amplification, contributing to osimertinib resistance.
Authors
- Derek De-Rui Huang (ORCID: https://orcid.org/0000-0002-3236-0321)
- Chen‐Yuan Tseng (ORCID: https://orcid.org/0000-0002-0383-3660)
- Jin‐Yuan Shih (ORCID: https://orcid.org/0000-0002-2854-5067)
- James Chih‐Hsin Yang (ORCID: https://orcid.org/0000-0002-5586-5138)
- Pei-Chen Tai
- Min‐Shu Hsieh (ORCID: https://orcid.org/0000-0002-0594-3732)
- Fang‐Yu Lin (ORCID: https://orcid.org/0000-0003-2943-6644)
- Shih-Yun Chou
- Wei‐Hsun Hsu (ORCID: https://orcid.org/0000-0002-6902-4719)
- Bin‐Chi Liao
- Hsin-Hui Tsai
- C.-H. Hsu
Institutions
- National Chung Hsing University (TW)
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- National Yang Ming Chiao Tung University (TW)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1186/s12929-025-01181-3
- Citations
- 1
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Taiwan University
- National Science and Technology Council