Efficacy in the reduction ratios of middle molecules with the use of medium cut-off dialyzers and reduced dialysate flows: a cohort study
HDx enabled by Theranova dialyzer significantly improved the removal of medium-molecular-weight uremic toxins compared to HF-HD at dialysate flow rates of 500 mL/min and 400 ml/min, with fewer serious adverse events and hospitalization events. These findings support the use of the environmentally sustainable dialysis treatment of HDx with dialysate flow rate of 400 ml/min.
Authors
- Daniel Ducuara (ORCID: https://orcid.org/0000-0003-0805-1446)
- Bengt Lindholm (ORCID: https://orcid.org/0000-0003-4269-4293)
- Javier Cely (ORCID: https://orcid.org/0000-0001-6544-1497)
- Jasmin I. Vesga (ORCID: https://orcid.org/0000-0001-8111-6395)
- Cesar Mauricio Doria
- David Andrés Camargo Mayorga (ORCID: https://orcid.org/0000-0002-5290-8251)
- Ángela Rivera (ORCID: https://orcid.org/0000-0002-2162-7131)
- Peter Rutherford (ORCID: https://orcid.org/0000-0003-2425-4358)
- Juan C. Castillo (ORCID: https://orcid.org/0000-0002-3164-0823)
- Mauricio Sanabria (ORCID: https://orcid.org/0000-0002-5111-9832)
- Viviana Orozco
Institutions
- Rafael Advanced Defense Systems (Israel) (IL)
- Universidad Autónoma de Bucaramanga (CO)
- Historic Deerfield (US)
- Karolinska Institutet (SE)
- Universidad Nacional de Colombia (CO)
- Instituto del Corazón de Bucaramanga (CO)
- Swiss Institute for Regenerative Medicine (CH)
- Stockholm Environment Institute (CO)
- Institute of Cardiology (CO)
- Colciencias (CO)
- Instituto Nacional de Salud (CO)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3389/fmed.2025.1663750
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Baxter International