Neural mechanism of HT7 electroacupuncture in myocardial ischemia: critical role of the paraventricular nucleus oxytocin system
PVN oxytocinergic neurons are both necessary and sufficient for the cardioprotective effects of EA at HT7. Chemogenetic regulation confirms a causal neurocardiac axis, providing mechanistic insights that support precision acupuncture therapies for ischemic heart disease.
Authors
- Hao-Sheng Wu
- Tong‐Tong Liu (ORCID: https://orcid.org/0000-0002-9935-2916)
- Chao Zhu (ORCID: https://orcid.org/0000-0001-9018-2132)
- Meiqi Zhou (ORCID: https://orcid.org/0000-0002-8798-7121)
- Shuai Cui (ORCID: https://orcid.org/0000-0003-1457-6759)
- Hang Su (ORCID: https://orcid.org/0000-0001-6970-4792)
- Pan Liu (ORCID: https://orcid.org/0000-0002-3066-652X)
- Xiaohui Liu (ORCID: https://orcid.org/0009-0007-0319-1366)
- Xinyi Zheng (ORCID: https://orcid.org/0000-0001-9308-428X)
- Li Zhu (ORCID: https://orcid.org/0000-0002-5364-4016)
- Shengbin Wu (ORCID: https://orcid.org/0000-0002-5069-5037)
Institutions
- Meridian Institute (US)
- Anhui University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3389/fnins.2025.1678938
- Citations
- 1
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 2.44