Histological efficacy of anti‐diabetic agents in <scp>MASH</scp> and the mediating role of weight loss: A network meta‐analysis
SGLT2 inhibitor and incretin-based agents improved fibrosis in MASH, with weight loss being a significant mediator. Targeting multiple incretin pathways, especially involving glucagon receptors, may offer greater MASH resolution. Dose-dependent effects were more prominent for MASH resolution than fibrosis improvement, indicating potential weight-loss-independent anti-fibrotic pathways.
Authors
- Rimesh Pal (ORCID: https://orcid.org/0000-0003-4859-9393)
- Sandip Pal
- Mainak Banerjee (ORCID: https://orcid.org/0000-0002-6656-8569)
Institutions
- Ramakrishna Mission Vidyamandira (IN)
- Rabindranath Tagore International Institute of Cardiac Sciences (IN)
- Vivekananda Institute of Medical Sciences (IN)
- Post Graduate Institute of Medical Education and Research (IN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1111/dom.70187
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35