Disease duration impacts intestinal gene expression profiles in Crohn’s disease but not in ulcerative colitis
Disease duration influences intestinal gene expression in CD but significantly less so in UC. The identified pathways and genes may inform development of differing biomarkers and treatment strategies in shorter versus longer standing CD.
Authors
- Bernhard Y. Renard (ORCID: https://orcid.org/0000-0003-4589-9809)
- Judy H. Cho (ORCID: https://orcid.org/0000-0002-7959-0466)
- Jean‐Frédéric Colombel (ORCID: https://orcid.org/0000-0001-6472-249X)
- Bruce E. Sands (ORCID: https://orcid.org/0000-0001-5762-5042)
- Drew Helmus (ORCID: https://orcid.org/0000-0001-6799-3674)
- Marla C. Dubinsky (ORCID: https://orcid.org/0000-0003-4968-5795)
- Susanne Ibing (ORCID: https://orcid.org/0000-0003-0445-7588)
- Christopher Tastad
- Ryan C. Ungaro (ORCID: https://orcid.org/0000-0001-8687-3758)
- Louis Cohen (ORCID: https://orcid.org/0000-0002-9925-5913)
- Carmen Argmann (ORCID: https://orcid.org/0000-0002-1110-8012)
- Sudha Visvanathan (ORCID: https://orcid.org/0000-0002-1170-9272)
- Miriam Mérad (ORCID: https://orcid.org/0000-0002-4481-7827)
- Erwin P. Böttinger (ORCID: https://orcid.org/0000-0001-6868-6676)
- Eric E. Schadt (ORCID: https://orcid.org/0000-0002-7892-8808)
- Mayte Suárez‐Fariñas (ORCID: https://orcid.org/0000-0001-8712-3553)
- Francesca Petralia (ORCID: https://orcid.org/0000-0001-5096-9854)
- A. K. Kukreja
Institutions
- Hasso Plattner Institute (DE)
- Boehringer Ingelheim (France) (FR)
- Center for Genomic Science (IT)
- Boehringer Ingelheim (United States) (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1093/ecco-jcc/jjaf179
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82