Development and Characterization of TMZ Loaded HPMC-Montmorillonite Composites

In particular, the use of natural and large surface area natural inorganic materials such as clay minerals as carrier systems or adsorbents is important in terms of low cost. This study investigated the utility of montmorillonite (Mt) clay in both its raw form and when modified with hydroxypropyl methylcellulose (HPMC) for the encapsulation and release of temozolomide (TMZ) active ingredient. For this purpose, the raw Mt clay was first purified using the sedimentation method. Then, six different formulations were prepared using Mt, HPMC, and TMZ in different composition ratios. The release of TMZ was evaluated under simulated stomach fluid conditions at varying time intervals. As a result of the release tests, it was determined that the optimum formulation (F-6) showed best controlled release of TMZ from HPMC modified Mt. The F-6 formulation exhibited a rapid TMZ release of 50% in the first 45 min. In the later period, it was determined that the oscillation occurred more slowly for 360 min and reached approximately 90%. Korsmeyer-Peppas and Hixson kinetics provided a clear explanation of the TMZ release of the generated formulations. Nonetheless, the presence of regulated drug diffusion (Fickian mechanism) and ion exchange mechanism is linked to n coefficient values in the Korsmeyer-Peppas model being smaller than 0.5.