Detection of macrotrabecular-massive hepatocellular carcinoma based on viscoelastic characteristics obtained by multifrequency magnetic-resonance elastography
Question Can MRE-based viscoelastic values identify the macrotrabecular-massive (MTM) subtype of HCC? Findings Tumor-c based on MRE has a unique diagnostic performance for identifying MTM-HCC; tumor stiffness correlates with proliferative and immune gene expression. Clinical relevance MRE-based stiffness is a noninvasive predictor of MTM-HCC, and high-stiffness tumors show upregulation of proliferation genes and downregulation of immune genes. These findings may guide personalized treatment, but larger studies are required to confirm clinical applicability.
Authors
- Yunjie Liao
- Jia Luo (ORCID: https://orcid.org/0000-0003-2796-358X)
- Hongpei Tan (ORCID: https://orcid.org/0000-0002-7856-4805)
- Pengfei Rong (ORCID: https://orcid.org/0000-0001-5473-1982)
- Zhenghui Mi (ORCID: https://orcid.org/0000-0002-6136-6861)
- Junhong Duan (ORCID: https://orcid.org/0000-0003-3706-5767)
- Yanling Liu (ORCID: https://orcid.org/0000-0002-2027-6464)
- Qi Liang (ORCID: https://orcid.org/0000-0002-0054-1478)
- Zhen Wang (ORCID: https://orcid.org/0000-0001-9499-0487)
- Qiyuan Chen (ORCID: https://orcid.org/0000-0001-6680-8799)
Institutions
- Central South University (CN)
- Hunan Cancer Hospital (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- European Radiology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1007/s00330-025-12024-y
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Central South University
- China Postdoctoral Science Foundation
- Xiangya Hospital, Central South University