Associations of MEG3 rs7158663, rs4081134 gene variants and Ki-67, p53, CK18 immunohistochemical markers with clinical features of pituitary neuroendocrine tumors
This study found that a higher p53 H-score was significantly associated with larger PitNET size and invasiveness. Negative CK18 staining was associated with non-functioning and invasive PitNETs. P53 expression and CK18 status may serve as useful prognostic markers in PitNETs.
Authors
- Rasa Liutkevičienė (ORCID: https://orcid.org/0000-0001-5395-923X)
- Jurgita Makštienė
- Lina Poškienė
- Monika Duseikaitė
- Sheng‐Nan Wu (ORCID: https://orcid.org/0000-0002-5208-3253)
- Vita Rovīte (ORCID: https://orcid.org/0000-0001-9368-5210)
- Enrika Pileckaitė
- Balys Remigijus Zaliunas
- Arimantas Tamašauskas (ORCID: https://orcid.org/0000-0002-1698-6957)
Institutions
- Lithuanian University of Health Sciences (LT)
- Latvian Biomedical Research and Study Centre (LV)
- Hospital of Lithuanian University of Health Sciences Kaunas Clinics (LT)
- National Cheng Kung University Hospital (TW)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3389/fendo.2025.1657520
- Citations
- 1
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Lietuvos Mokslo Taryba