The diagnostic value of inflammatory markers in bone metastasis of prostate cancer at initial prostate biopsy

We present a novel, internally validated nomogram that synergistically combines inflammatory and clinical markers to accurately predict bone metastasis in PCa at initial diagnosis. This practical and cost-effective tool has the potential to aid clinicians in risk stratification, guide personalized diagnostic imaging decisions, and ultimately help reduce unnecessary bone scans, particularly in resource-conscious settings. Our findings underscore the pivotal role of the systemic inflammatory response in PCa metastasis.