Antibodies to unknown antigens other than swine leukocyte antigens on GTKO/β4GalNT2KO pig cells are associated with AHXR after pig-to-rhesus monkey kidney transplantation
These data suggest that elicited antibodies to "neoantigens", e.g., non-SLA, play a role in AHXR after GTKO/β4GalNT2KO-based pig kidney transplantation in non-human primates.
Authors
- Dengke Pan (ORCID: https://orcid.org/0000-0002-7994-1465)
- Haiyun Jiang
- Jiaxiang Du (ORCID: https://orcid.org/0009-0005-3798-284X)
- Yi Wang (ORCID: https://orcid.org/0000-0001-7152-0757)
- Songzhe He (ORCID: https://orcid.org/0009-0004-5022-1351)
- Yuxiang Chen (ORCID: https://orcid.org/0000-0003-4733-123X)
- Tao Li (ORCID: https://orcid.org/0000-0002-9637-778X)
- Hongtao Jiang
Institutions
- Chengdu Organic Chemicals (China) (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1663702
- Primary Topic
- Xenotransplantation and immune response
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China