Efficacy of Dupilumab in a Woman With Severe Asthma Complicated by Eosinophilic Sinusitis and a Desire to Have a Baby: A Case Report
Dupilumab is an effective biologic therapy for severe asthma; however, its safety and efficacy in women undergoing infertility treatment remain uncertain. A woman in her late 30s with severe asthma and eosinophilic chronic rhinosinusitis underwent assisted reproductive technology while receiving dupilumab. The medication was discontinued upon confirmation of pregnancy. Asthma control improved significantly with dupilumab. The patient conceived successfully and delivered a healthy infant. Dupilumab may be a viable treatment option for women with severe asthma undergoing fertility treatment, though additional safety data are needed to support its use during conception and pregnancy.
Authors
- Koichi Yamaguchi (ORCID: https://orcid.org/0000-0002-8074-379X)
- Yuri Sawada
- Yurino Nagata
- Daisuke Higeta (ORCID: https://orcid.org/0000-0002-6981-9722)
- Noriaki Sunaga (ORCID: https://orcid.org/0000-0002-5966-4579)
- Yasuhiko Koga (ORCID: https://orcid.org/0000-0002-4974-9026)
- Hiroaki Tsurumaki (ORCID: https://orcid.org/0000-0003-0837-9329)
- Kazuaki Chikamatsu (ORCID: https://orcid.org/0000-0002-7739-0102)
- Masakiyo Yatomi (ORCID: https://orcid.org/0000-0001-6840-515X)
- Kenichiro Hara (ORCID: https://orcid.org/0000-0003-4212-7352)
- Haruka Aoki‐Saito (ORCID: https://orcid.org/0000-0002-4303-330X)
- Toshitaka Maeno (ORCID: https://orcid.org/0000-0002-8428-1617)
- Takeshi Hisada (ORCID: https://orcid.org/0000-0002-3862-1887)
- Kuniyoshi Kuno
- Daisuke Shimizu (ORCID: https://orcid.org/0009-0003-8725-1987)
- Yosuke Miura
- Mari Sato (ORCID: https://orcid.org/0000-0002-5680-7167)
- Akari Neoi
Institutions
- Gunma University (JP)
- Toshima Hospital (JP)
- Gunma University Hospital (JP)
Publication Details
- Journal
- Clinical Case Reports
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/ccr3.70982
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00