Alternate day fasting alleviates neuroinflammation in diabetic mice by regulating δ-valerobetaine-carnitine-microglia axis via enrichment of Akkermansia muciniphila
Our study sheds light on the gut-liver-brain metabolic axis mechanism on the protective role of ADF in T1D-associated neuroinflammation and exploratory behavioral disorders and AKK bacteria exert as a key mediator. Video Abstract.
Authors
- Kaiyan Gong
- Qingpeng Cai (ORCID: https://orcid.org/0000-0001-6451-9299)
- Hong Zheng (ORCID: https://orcid.org/0000-0002-2054-1491)
- Jiahui Ma
- Xiaoli Yin (ORCID: https://orcid.org/0000-0003-1485-5475)
- Wenjun Wu (ORCID: https://orcid.org/0000-0002-2528-4893)
- Hao Ji (ORCID: https://orcid.org/0009-0005-5667-5861)
- Zhen Wang (ORCID: https://orcid.org/0000-0001-9289-4889)
- Mengjun Wu (ORCID: https://orcid.org/0009-0000-5580-0249)
- Yiyuan Pan (ORCID: https://orcid.org/0000-0001-7736-4951)
- Shuhui Zhang
Institutions
- Wenzhou University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1186/s40168-025-02196-6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wenzhou Medical University
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province