Placental mTOR signalling links mitochondrial dysfunction, nutrient transport and neonatal beta cell perturbations in mice
Our novel in vivo model of direct placental mTOR-driven FGR provides strong evidence linking placental dysfunction and amino acid transport to proper programming of beta cells in early life.
Authors
- Seokwon Jo (ORCID: https://orcid.org/0000-0002-8989-4893)
- Sarah N. Larson (ORCID: https://orcid.org/0000-0002-1712-7994)
- Elizabeth A. Morgan (ORCID: https://orcid.org/0000-0001-5880-9337)
- Megan Beetch (ORCID: https://orcid.org/0000-0003-4338-4350)
- Brian Akhaphong (ORCID: https://orcid.org/0000-0002-1268-6623)
- Briana Clifton (ORCID: https://orcid.org/0000-0002-3820-8611)
- Emilyn U. Alejandro (ORCID: https://orcid.org/0000-0002-7941-8439)
- Alicia Wong (ORCID: https://orcid.org/0000-0002-1018-3539)
- A. Hausmann
- Eunice Oribamise
Institutions
- University of Minnesota (US)
- University of Minnesota Medical Center (US)
- UConn Health (US)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1007/s00125-025-06542-z
- Citations
- 1
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- University of Minnesota
- Clinical and Translational Science Institute, University of Minnesota