DABCO-promoted reaction sequence of β-nitro alcohols and α-oxoaldehydes: construction of diverse tetrahydrofurans and total synthesis of (+)-bruguierol B
A DABCO-promoted highly efficient reaction sequence has been developed, where β-nitro alcohols reacted smoothly with α-oxoaldehydes to afford diverse tetrahydrofuran derivatives. This strategy enabled the first total synthesis of (+)-bruguierol B.
Authors
- Yankai Liu (ORCID: https://orcid.org/0000-0002-6559-2348)
- Xuejiao Lv
- Yu-Xia Lu
Institutions
- Qingdao National Laboratory for Marine Science and Technology (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1039/d5qo01330e
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00