Exenatide, a glucagon-like peptide-1 receptor agonist, may negatively impact bone healing in rats: histopathological, biochemical, and in silico findings
Although the data obtained from the in vitro analyses in this study were verified using molecular docking, it should be noted that its design is preclinical. Given the widespread clinical use of GLP-1 receptor agonists in the management of type 2 diabetes mellitus (T2DM), our research findings may have translational relevance. Although derived from an experimental animal model, these results suggest that GLP-1 agonists such as EXE can exert additional effects on bone healing and inflammatory processes, thus warranting further studies, including controlled clinical investigations, to elucidate the potential implications for patient care.
Authors
- Fatih Uğur (ORCID: https://orcid.org/0000-0001-6109-8425)
- Mehmet Akif Bildirici (ORCID: https://orcid.org/0000-0003-3062-5856)
- Candemir Özcan (ORCID: https://orcid.org/0000-0003-2186-5305)
- Ersin Güner (ORCID: https://orcid.org/0000-0001-6340-5441)
- Mehmet Albayrak (ORCID: https://orcid.org/0000-0002-4074-7024)
- Recep Taşkın (ORCID: https://orcid.org/0000-0002-3656-6140)
- Ayşe Başak Dellalbaşı (ORCID: https://orcid.org/0000-0002-5796-5298)
- İbrahim Yılmaz (ORCID: https://orcid.org/0000-0003-2003-6337)
- Nurtaç Asa Sarıkaş (ORCID: https://orcid.org/0000-0002-2170-0300)
Institutions
- Ministry of Health (TR)
- Konya Numune Hastanesi (TR)
- Istanbul University (TR)
- University of Health Sciences Antigua (AG)
- Kastamonu University (TR)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1186/s13018-025-06300-2
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00