Limited effects of non-steroidal anti-inflammatory drugs (NSAIDs) on imaging outcomes in osteoarthritis: observational data from the osteoarthritis initiative (OAI)
New NSAID use was not associated with MRI-detected synovitis over 4 years but had a modest association with reduced structural cartilage damage progression. This effect was more pronounced in individuals with an inflammatory imaging phenotype.
Authors
- Michael C. Nevitt (ORCID: https://orcid.org/0000-0002-6988-7530)
- Charles E. McCulloch (ORCID: https://orcid.org/0000-0002-1279-6179)
- Gabby B. Joseph (ORCID: https://orcid.org/0000-0002-7736-123X)
- Johanna Luitjens
- Nancy E. Lane (ORCID: https://orcid.org/0000-0002-0177-2198)
- Katharina Ziegeler (ORCID: https://orcid.org/0000-0002-9763-2420)
- Virginie Kreutzinger (ORCID: https://orcid.org/0009-0005-7378-1068)
- Thomas M. Link (ORCID: https://orcid.org/0000-0002-2850-8143)
- John A. Lynch (ORCID: https://orcid.org/0000-0003-3624-2741)
Institutions
- University of California, San Francisco (US)
- Institute for Musculoskeletal Health (AU)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1186/s12891-025-09172-z
- Citations
- 4
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.67
Funders
- U.S. Department of Health and Human Services
- Pfizer
- GlaxoSmithKline
- Novartis Pharmaceuticals Corporation
- National Institutes of Health