Effects of glutaminase 1 inhibitor on rotator cuff derived cells: a preliminary report in 12 patients
This study showed that GLS1 was upregulated in the degenerated rotator cuff, and that the administration of a GLS1 inhibitor decreased inflammation and aging markers while increasing cell viability and tendon markers in rotator cuff-derived cells. These results indicate that GLS1 inhibitors exert anti-inflammatory effects in rotator cuff tears, prevent age-related degeneration of the rotator cuff, and promote tendon repair.
Authors
- Yutaka Mifune (ORCID: https://orcid.org/0000-0002-9612-5785)
- Takahiro Furukawa (ORCID: https://orcid.org/0000-0002-1681-6974)
- Issei Shinohara (ORCID: https://orcid.org/0000-0002-4122-7119)
- Yuichi Hoshino (ORCID: https://orcid.org/0000-0001-6142-8973)
- Tomoya Yoshikawa (ORCID: https://orcid.org/0000-0002-7613-5521)
- Takehiko Matsushita (ORCID: https://orcid.org/0000-0001-6616-0398)
- Tomoyuki Matsumoto (ORCID: https://orcid.org/0000-0003-4587-0029)
- Masaya Kusunose
- Shintaro Mukohara (ORCID: https://orcid.org/0000-0002-3615-2167)
- Ryosuke Kuroda (ORCID: https://orcid.org/0000-0001-5097-7264)
- Shuya Tanaka (ORCID: https://orcid.org/0000-0001-6349-5993)
- Atsuyuki Inui (ORCID: https://orcid.org/0000-0002-0806-6579)
- Hanako Nishimoto (ORCID: https://orcid.org/0000-0001-5588-7145)
- Tatsuo Kato
Institutions
- Kobe University (JP)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1186/s12891-025-09105-w
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00