Elevated maternal serum aminotransferase in early pregnancy associated with early-onset preeclampsia: A cohort study of 116,967 pregnancies in Shanghai, China
Elevated levels of ALT, AST and their ratios in early pregnancy were associated with an increased risk of PE, especially early-onset PE. Therefore, screening for aminotransferase levels in early pregnancy could be considered for identification of women at high risk of developing liver dysfunction-related PE, or even early-onset PE.
Authors
- Shutian Zhang (ORCID: https://orcid.org/0000-0003-2356-4397)
- Yunyun Cao (ORCID: https://orcid.org/0000-0002-5718-0562)
- Jinwen Zhang (ORCID: https://orcid.org/0000-0001-8828-114X)
- Li Li (ORCID: https://orcid.org/0000-0001-6746-4297)
- Juan Li (ORCID: https://orcid.org/0000-0003-3898-9988)
- Weibin Wu (ORCID: https://orcid.org/0000-0002-6583-3914)
- Jing Zhu (ORCID: https://orcid.org/0000-0002-1646-2125)
- Yulai Zhou (ORCID: https://orcid.org/0000-0002-0606-6786)
- Yanlin Wang (ORCID: https://orcid.org/0000-0003-0995-2393)
Institutions
- Shanghai Jiao Tong University (CN)
- Ministry of Agriculture (BW)
- International Peace Maternity & Child Health Hospital (CN)
- Shanghai Institute of Hematology (CN)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1186/s12884-025-08107-9
- Citations
- 2
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 4.11
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities