High fat diet exacerbated glycolipid metabolism disorder in kidney Yang deficiency rats by interfering with IRS 1-PI3K (p85) -Akt-GLUT 4 pathway
KYD predisposes rats to visceral fat accumulation, dyslipidemia, and fatty liver despite lower weight gain. Mechanistically, the impairment of the IRS1-Akt-PI3K(p85)-GLUT4 signaling pathway in KYD compromises insulin action, exacerbating lipid metabolic disturbances under HFD. These findings highlight the dietary risks for individuals with KYD and emphasize the need for targeted interventions aimed at specific metabolic pathways.
Authors
- Chunping Tang (ORCID: https://orcid.org/0000-0002-3568-7389)
- Yunqiao Wang (ORCID: https://orcid.org/0000-0001-7300-8570)
- Han Li (ORCID: https://orcid.org/0000-0002-6745-1987)
- Zihui Xu (ORCID: https://orcid.org/0000-0001-8251-4774)
- M. S. Long (ORCID: https://orcid.org/0000-0002-1561-6604)
- Bin Chen (ORCID: https://orcid.org/0000-0001-8858-874X)
- Bo Liu (ORCID: https://orcid.org/0000-0002-2769-5354)
- Wei Zheng (ORCID: https://orcid.org/0000-0003-1588-2803)
- Weihong Li (ORCID: https://orcid.org/0000-0003-4942-822X)
- Jing Lü (ORCID: https://orcid.org/0009-0001-2901-6300)
Institutions
- Army Medical University (CN)
- Daping Hospital (CN)
- Xinqiao Hospital (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1186/s12944-025-02721-4
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Army Medical University