Database analysis reveals endophilin A expression as a marker of metastasis and prognosis in breast cancer
Based on our findings, it is possible to conclude that endophilin A isoforms-long recognised for orchestrating endocytosis and metastatic behaviour-may represent a critical molecular fulcrum in breast cancer progression. In particular, elevated expression of endophilin A2 (SH3GL1) and SH3GL2 strongly correlates with poor prognosis and node-positive breast cancer, highlighting their potential as promising biomarkers for breast cancer assessment.
Authors
- Sohidul Islam (ORCID: https://orcid.org/0000-0003-4003-2544)
- Vikrant Mehta (ORCID: https://orcid.org/0000-0002-9523-3928)
- Harit Kasana (ORCID: https://orcid.org/0000-0001-9315-7784)
- Harish Chander (ORCID: https://orcid.org/0000-0001-9427-2936)
Institutions
- Baylor College of Medicine (US)
- Government of India (IN)
- National Institute of Health and Family Welfare (IN)
- Ministry of Health and Family Welfare (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1007/s12672-025-03382-6
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00