PARP inhibition augments immunomodulatory function of mesenchymal stem/stromal cells by promoting STAT1 phosphorylation
Our study indicates that like its pro-inflammatory role in macrophages, PARP also functions to undermine the immunosuppressive effects of MSCs, and PARP inhibition represents a strategy to further unleash the immunoregulatory power of MSCs.
Authors
- Jiankai Fang (ORCID: https://orcid.org/0000-0002-3791-969X)
- Xiao Su (ORCID: https://orcid.org/0009-0000-5974-1418)
- Chao Feng (ORCID: https://orcid.org/0000-0003-3259-562X)
- Pixia Gong (ORCID: https://orcid.org/0000-0002-7766-3270)
- Jinyi Tian (ORCID: https://orcid.org/0000-0002-5336-1884)
- Zhenzhen Meng
- Yufang Shi (ORCID: https://orcid.org/0000-0001-8964-319X)
- Tingting Yang (ORCID: https://orcid.org/0000-0002-5220-588X)
- Guofu Sun
- Changshun Shao (ORCID: https://orcid.org/0000-0003-2618-9342)
- Yanan Li (ORCID: https://orcid.org/0000-0002-2224-9451)
- Tingting Wang (ORCID: https://orcid.org/0000-0002-0703-9739)
- Rui Liu (ORCID: https://orcid.org/0000-0002-5002-7311)
- Peishan Li (ORCID: https://orcid.org/0000-0002-6881-396X)
- Lijuan Cao (ORCID: https://orcid.org/0000-0003-4581-0085)
- Wen Li (ORCID: https://orcid.org/0000-0002-2289-6894)
- Dongyan Zhao
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1186/s13287-025-04663-1
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Soochow University
- Basic Research Program of Jiangsu Province