Ten mouse organs proteome and metabolome atlas from adult to aging
This study provides a multi-omics atlas of multi-organ aging, revealing both intra- and inter-organ similarities and heterogeneities. These findings offer valuable insights into the molecular mechanisms underlying geriatric health decline and serve as a foundational resource for organism-systematic early warning and targeted interventions against aging-associated pathologies.
Authors
- Xinwen Ding (ORCID: https://orcid.org/0000-0001-6259-9504)
- Sunfengda Song
- Zhixiao Xu (ORCID: https://orcid.org/0000-0003-3110-549X)
- Yi Ding (ORCID: https://orcid.org/0000-0003-1356-6401)
- Shuang Zhang (ORCID: https://orcid.org/0000-0003-4556-2333)
- Qingwen Wang (ORCID: https://orcid.org/0000-0001-5988-9922)
- Xianting Ding (ORCID: https://orcid.org/0000-0002-1549-3499)
- Lai Jiang (ORCID: https://orcid.org/0000-0003-0998-1389)
- Aiting Wang (ORCID: https://orcid.org/0000-0003-1390-1660)
- Youming Chen
Institutions
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
- State Key Laboratory of Oncogene and Related Genes (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1186/s13073-025-01535-4
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Shanghai Municipal Education Commission
- Shanghai Jiao Tong University