Discovery and Validation of Molecular Biomarkers for Differentiation of Nondysplastic Barrett’s Esophagus from High-grade Dysplasia and Esophageal Adenocarcinoma
This study demonstrates that combining epigenetic and genomic biomarkers across minimally invasive sampling methods can accurately distinguish HGD/esophageal adenocarcinoma from nondysplastic Barrett's esophagus, offering promising, less invasive strategies to improve BE surveillance and enable endoscopic therapy for esophageal adenocarcinoma prevention and treatment.
Authors
- Herbert C. Wolfsen (ORCID: https://orcid.org/0000-0002-6957-522X)
- Arvind J. Trindade (ORCID: https://orcid.org/0000-0002-4132-0014)
- Prasad G. Iyer (ORCID: https://orcid.org/0000-0002-9822-1420)
- William R. Taylor (ORCID: https://orcid.org/0009-0001-2902-0158)
- Panwen Wang (ORCID: https://orcid.org/0000-0002-4614-8970)
- John B. Kisiel (ORCID: https://orcid.org/0000-0002-3840-5324)
- Allon Kahn (ORCID: https://orcid.org/0000-0002-1685-0865)
- Melissa Passe
- Patrick H. Foote (ORCID: https://orcid.org/0009-0001-9877-4797)
- Francisco C. Ramirez (ORCID: https://orcid.org/0000-0003-4731-4982)
- Caroline L. Matchett (ORCID: https://orcid.org/0000-0003-0663-826X)
- Douglas W. Mahoney (ORCID: https://orcid.org/0000-0001-5144-0645)
- Jeanette E. Eckel‐Passow (ORCID: https://orcid.org/0000-0002-6113-1114)
- Seth W. Slettedahl (ORCID: https://orcid.org/0000-0003-3398-3608)
- Calise K. Berger (ORCID: https://orcid.org/0009-0006-1407-7895)
- Vani J. Konda (ORCID: https://orcid.org/0000-0002-9932-8780)
- Don C. Codipilly (ORCID: https://orcid.org/0000-0003-3197-0539)
- Zhifu Sun (ORCID: https://orcid.org/0000-0001-8461-7523)
- Swathi Eluri (ORCID: https://orcid.org/0000-0002-2839-1440)
- Ramona Lansing
- Cadman L. Leggett (ORCID: https://orcid.org/0000-0002-0495-3795)
- Collin E. Chalmers
- Caryn E. Anderson
Institutions
- Rutgers, The State University of New Jersey (US)
- Mayo Clinic (US)
- Baylor University (US)
- Jacksonville College (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic Hospital (US)
- Mayo Clinic in Florida (US)
- Baylor Scott & White Health (US)
Publication Details
- Journal
- Cancer Prevention Research
- Published
- 2025-10-07
- DOI
- https://doi.org/10.1158/1940-6207.capr-25-0215
- Citations
- 2
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- National Institutes of Health