Deep Fungal Infection of the Skin with Two Rare Fungi in a Dog Being Treated with Immunosuppressant Therapy: A Case Report

Deep fungal skin infections in dogs being treated with immunosuppressant therapy pose a clinical challenge, balancing effective antifungal therapy with a sufficient immune function to control the infection whilst maintaining good control over the original disease. This case report describes the clinical presentation, diagnosis, and outcome of a dog with a concurrent deep fungal infection of the skin with two rare fungi, <i>Purpureocillium sodanum</i> and <i>Alternaria rosae</i>, and this is the first time this agents has been described in veterinary medicine. Challenges included fungal infections at multiple sites and drug-drug interactions between necessary immunosuppressive therapy and antifungals. Persistent lesions and limited therapeutic success emphasise the need for clinicians' awareness, early diagnosis, individualised case management, and advances in immunosuppressive protocols.