Identification and regulation of an alternative PTS for disaccharide utilization in <i>Clostridium acetobutylicum</i>

Cellulose, the most abundant organic compound on Earth, is primarily found in plant cell walls and can be broken down into sugars such as cellobiose. These sugars are crucial for microbial fermentation, especially in biofuel production. <i>Clostridium acetobutylicum</i>, a promising microorganism for producing short-chain alcohol chemicals, can utilize cellulose degradation products as a carbon source for fermentation. This study identifies the transport systems involved in the utilization of cellobiose and other disaccharides in <i>C. acetobutylicum</i> and analyzes their regulatory mechanisms. Understanding these pathways is essential for enhancing biofuel production from plant biomass.