8267200 Biological effects of laboratory technicians’ exposure to ionizing radiation and other environmental stressors

<h3>Objectives</h3> Diagnostic X-rays are the largest man-made source of radiation exposure. Although diagnostic X-rays provide great assistance, that their use involves some risk of adverse health effects is not commonly accepted. The exposure of individuals is rare and only prescription base. However, X-ray machine operators are exposed to these radiations on daily basis. In addition, the awareness of laboratory technicians about radiation exposure and associated adverse health effects is minimal. This research study is planned with the aim to assess combined carcinogenicity of X-rays and ELF MF in the form molecular mechanism i.e., DNA damage, disruption of antioxidant enzyme activities, and the generation of reactive oxygen species among X-rays technicians and their controls. <h3>Material and Methods</h3> The study participants will include healthy X-ray machine operators and their controls; matched with gender and age (± 5 years). Blood samples will be collected for the assessment of biological markers. Data about effect modifiers and other confounding factors i.e., smoking, socioeconomic status, etc., will be collected through a designed questionnaire. The data will be compared between the groups and analyzed using adjusted and un-adjusted regression analysis in R statistical software. <h3>Results</h3> Only a few studies have been conducted investigating the association between X-rays exposure of laboratory technicians and adverse health effects and no study has been conducted on the combined exposure of X-ray radiation in the laboratory workers and ELF MF, previously. The study results will be helpful both in assessing the adverse health effects of X-rays and in creating awareness amongst laboratory technicians, radiologists and other relevant health workers to keep the radiation exposure as low as possible. In addition, the study will be valuable for policy makers to prioritize occupational safety.