Emergence of ST11 <i>Klebsiella pneumoniae</i> co-carrying <i>bla</i> <sub>KPC-2</sub> and <i>bla</i> <sub>IMP-8</sub> on conjugative plasmids

This study is the first to report the co-existence of <i>bla</i><sub>KPC-2</sub> and <i>bla</i><sub>IMP-8</sub> in an ST11 <i>Klebsiella pneumoniae</i> strain, underscoring the clinical threat posed by these carbapenemase genes. The identification of <i>bla</i><sub>KPC-2</sub> on an IncFII/IncR hybrid plasmid, coupled with the successful conjugation of both resistance genes, highlights the significant potential for horizontal gene transfer and multidrug-resistant dissemination. These findings advance our understanding of plasmid-mediated resistance and emphasize the urgent need for enhanced monitoring and infection control strategies to mitigate the spread of such high-risk strains.

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Publication Details

Journal
Microbiology Spectrum
Published
2025-10-08
DOI
https://doi.org/10.1128/spectrum.03345-24
Citations
2
Primary Topic
Antibiotic Resistance in Bacteria
Type
article
Field-Weighted Citation Impact
1.18
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article

Emergence of ST11 Klebsiella pneumoniae co-carrying bla KPC-2 and bla IMP-8 on conjugative plasmids

Tian Hu, Beiwen Zheng, Lu Gong, Huishuang Yang et al.
2 citations
Microbiology Spectrum
Antibiotic Resistance in Bacteria
1.18
article

Emergence of ST11 Klebsiella pneumoniae co-carrying bla KPC-2 and bla IMP-8 on conjugative plasmids

Tian Hu, Beiwen Zheng, Lu Gong, Huishuang Yang, Weidong Zhu, Xiaolu Yang, Haowei Ye, Bingyou Yin, Zhenghao Lou, Xinrui Wang, Kun Wang
article en
2 citations

Abstract

This study is the first to report the co-existence of <i>bla</i><sub>KPC-2</sub> and <i>bla</i><sub>IMP-8</sub> in an ST11 <i>Klebsiella pneumoniae</i> strain, underscoring the clinical threat posed by these carbapenemase genes. The identification of <i>bla</i><sub>KPC-2</sub> on an IncFII/IncR hybrid plasmid, coupled with the successful conjugation of both resistance genes, highlights the significant potential for horizontal gene transfer and multidrug-resistant dissemination. These findings advance our understanding of plasmid-mediated resistance and emphasize the urgent need for enhanced monitoring and infection control strategies to mitigate the spread of such high-risk strains.

Microbiology SpectrumVol. 13(11)
Zhejiang Chinese Medical University (CN), Cluster in Biomedicine (IT), Collaborative Research Group (AU), Zhujiang Hospital (CN), First Affiliated Hospital of Henan University of Science and Technology (CN), Center for Innovation (US), Hangzhou Hospital of Traditional Chinese Medicine (CN), The Third Affiliated Hospital of Zhejiang Chinese Medical University (CN), First Affiliated Hospital Zhejiang University (CN), China Agricultural University (CN), Zhejiang University (CN)
Openalex Percentile: Top 19%
Antibiotic Resistance in Bacteria
1.18
DOIOpen Access PDFOpenAlex
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Emergence of ST11 <i>Klebsiella pneumoniae</i> co-carrying <i>bla</i> <sub>KPC-2</sub> and <i>bla</i> <sub>IMP-8</sub> on conjugative plasmids — Tian Hu, Beiwen Zheng, et al. · Microbiology Spectrum (2025) | TGRS Research Map | TGRS