Three new phenylpropanoids from <i>Atractylodes japonica</i> Koidz. ex kitam
Three new phenylpropanoids (<b>1-3</b>), together with eighteen known phenylpropanoids (<b>4-21</b>), were isolated from a 70% aqueous EtOH extract of the rhizomes of <i>Atractylodes japonica</i> Koidz. ex Kitam. Their structures were elucidated by spectroscopic techniques, including 1D, 2D NMR spectra and HR-ESI-MS. All the isolated compounds were evaluated for cytotoxicity activity by CCK-8 assay. Compounds <b>1</b>, <b>11</b> and <b>13</b> exhibited moderate activities with IC<sub>50</sub> values in the range of 34.19-48.38 μM against human cancer (BGC-823, HepG-2, HeLa) cell lines.
Authors
- Yuanyuan Zhou (ORCID: https://orcid.org/0000-0002-3684-6126)
- Hailong Yu (ORCID: https://orcid.org/0000-0002-1557-7465)
- Bing‐You Yang (ORCID: https://orcid.org/0000-0002-2310-2750)
- Yan Liu
- Jie Sun (ORCID: https://orcid.org/0009-0007-7190-0523)
- Zhao Sun
- Zhen-Xing Fang
- Jing Wang (ORCID: https://orcid.org/0000-0001-7431-8925)
Institutions
- Heilongjiang University of Chinese Medicine (CN)
- Heilongjiang Academy of Sciences (CN)
- National Quality Inspection and Testing Center for Surveying and Mapping Products (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1080/14786419.2025.2569806
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00