Comparison of Different Sites of Microbiota Shows Increased <i>Pseudomonas</i> Species in the Gut Mucosa in Inflammatory Bowel Disease
The opportunistic pathogenic bacterium Pseudomonas species is more prevalent in the gut mucosa of patients with IBD. This indicates a disruption of the gut barrier with increasing mucosal colonization or invasion of the bacteria. The finding is independent of clinical metadata and confounders and occurs in new-onset IBD but not in non-IBD intestinal inflammation, which suggests disease specificity.
Authors
- Katja Steiger (ORCID: https://orcid.org/0000-0002-7269-5433)
- Niklas Thur
- Fabian Geisler (ORCID: https://orcid.org/0000-0003-1545-485X)
- Johannes R. Wießner
- Henrik Einwächter (ORCID: https://orcid.org/0000-0002-8823-5116)
- Ursula Ehmer (ORCID: https://orcid.org/0000-0002-0441-1953)
- Lucia Liotta
- Monica Steffi Matchado (ORCID: https://orcid.org/0000-0002-2058-7924)
- Christina Gassner
- Mayada Elnegouly (ORCID: https://orcid.org/0000-0002-2025-7423)
- Moritz Jesinghaus (ORCID: https://orcid.org/0000-0002-0018-5661)
- Veit Phillip (ORCID: https://orcid.org/0000-0002-0921-2523)
- Moritz Middelhoff (ORCID: https://orcid.org/0000-0001-8425-3985)
- Dirk Haller (ORCID: https://orcid.org/0000-0002-6977-4085)
- Lisa Fricke (ORCID: https://orcid.org/0000-0002-9268-0546)
- H. Carlo Maurer (ORCID: https://orcid.org/0000-0002-2193-6014)
- Mohsen Pourjam (ORCID: https://orcid.org/0000-0003-3904-8100)
- Markus List
- Simon Weidlich (ORCID: https://orcid.org/0000-0001-7193-2778)
- Klaus Neuhaus (ORCID: https://orcid.org/0000-0002-6020-2814)
- Michael Quante (ORCID: https://orcid.org/0000-0002-8497-582X)
- Marc Ringelhan (ORCID: https://orcid.org/0000-0003-3131-5657)
- Matthias Treiber (ORCID: https://orcid.org/0000-0002-1005-3240)
- Jörg Ulrich (ORCID: https://orcid.org/0000-0002-4949-3374)
- Ulrich Mayr (ORCID: https://orcid.org/0000-0002-5235-5327)
- Tobias Lahmer (ORCID: https://orcid.org/0000-0003-1008-5311)
- Chiara Hennig
- Klaus‐Peter Janssen (ORCID: https://orcid.org/0000-0002-4707-7887)
- David Schult (ORCID: https://orcid.org/0000-0002-3022-799X)
- Bärbel Stecher (ORCID: https://orcid.org/0000-0002-7445-5193)
- Sebastian Rasch (ORCID: https://orcid.org/0000-0002-7917-8017)
- Ulrike Bauer (ORCID: https://orcid.org/0000-0002-6317-3609)
- Leona Arps
- Mohamed Abdelhafez (ORCID: https://orcid.org/0000-0003-0659-6274)
- Roland M. Schmid (ORCID: https://orcid.org/0000-0002-5751-7313)
- Julius Shakhtour
- Markus Heilmeier
Institutions
- University of Freiburg (DE)
- Philipps University of Marburg (DE)
- Universitätsklinikum Gießen und Marburg (DE)
- University Medical Center Freiburg (DE)
- German Center for Infection Research (DE)
- Leibniz-Institute for Food Systems Biology at the Technical University of Munich (DE)
- Technical University of Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1093/ibd/izaf185
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft