A novel cryoprecipitate-enriched PRP (Cryo-PRP) gel with enhanced mechanical strength and regenerative capacity accelerates enterocutaneous fistula healing

Cryo-PRP demonstrates superior mechanical and biological properties over conventional PRP, effectively promoting tissue regeneration and reducing inflammation in an ECF model. These findings support Cryo-PRP as a safe, autologous, and minimally invasive therapeutic strategy for ECF management.

Authors

Xianlei Cai (ORCID: https://orcid.org/0000-0003-2074-2821)
Hua Ye (ORCID: https://orcid.org/0000-0001-7613-6041)
Zhenzhen Wang (ORCID: https://orcid.org/0000-0003-4645-0958)
Yifan Ma (ORCID: https://orcid.org/0000-0002-1382-3247)
Bin Hu (ORCID: https://orcid.org/0000-0002-7609-8222)
Zimo Zhao
Qiu Han

Institutions

Ningbo Medical Center Lihuili Hospital (CN)
Ningbo Institute of Industrial Technology (CN)

Publication Details

Journal: Frontiers in Bioengineering and Biotechnology
Published: 2025-10-08
DOI: https://doi.org/10.3389/fbioe.2025.1668608
Primary Topic: Periodontal Regeneration and Treatments
Type: article
Field-Weighted Citation Impact: 0.00

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article

A novel cryoprecipitate-enriched PRP (Cryo-PRP) gel with enhanced mechanical strength and regenerative capacity accelerates enterocutaneous fistula healing

Xianlei Cai, Hua Ye, Zhenzhen Wang, Yifan Ma et al.

Oct 8, 2025

Frontiers in Bioengineering and Biotechnology

Periodontal Regeneration and Treatments

article

A novel cryoprecipitate-enriched PRP (Cryo-PRP) gel with enhanced mechanical strength and regenerative capacity accelerates enterocutaneous fistula healing

Xianlei Cai, Hua Ye, Zhenzhen Wang, Yifan Ma, Bin Hu, Zimo Zhao, Qiu Han

October 8, 2025article en

Abstract

Cryo-PRP demonstrates superior mechanical and biological properties over conventional PRP, effectively promoting tissue regeneration and reducing inflammation in an ECF model. These findings support Cryo-PRP as a safe, autologous, and minimally invasive therapeutic strategy for ECF management.

Frontiers in Bioengineering and BiotechnologyVol. 13

Ningbo Medical Center Lihuili Hospital (CN), Ningbo Institute of Industrial Technology (CN)

Openalex Percentile: Top 61%

Periodontal Regeneration and Treatments

DOI Open Access PDF OpenAlex

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A novel cryoprecipitate-enriched PRP (Cryo-PRP) gel with enhanced mechanical strength and regenerative capacity accelerates enterocutaneous fistula healing — Xianlei Cai, Hua Ye, et al. · Frontiers in Bioengineering and Biotechnology (2025) | TGRS Research Map | TGRS