Study of combination the antifungal with the antibacterial against bacteria Staphylococcus aureus isolated from skin infection

Bacteria are one of the factors that cause skin infections. Staphylococcus aureus was the most prevalent type, and because of the frequent use of antibacterial, many of them have become resistant. From this principle, this study was conducted at the Faculty of Medical Technology, Islamic University, from January 2023 to May 2023, and the aim of the study is to investigate and detect bacteria that cause skin infections and test the antifungal synergy of with the antibacterials. the results show (Staphylococcus aureus 45%, Escherichia coli,35%, pseudomonas aeruginosa 8%, Staphylococcus epidermidis 5%, klebsiella pneumoniae %4 and proteus mirabilis 1%) and it is necessary to test new antibiotic. The combination of the antifungal itraconazole with the antibacterial amoxicillin, norfloxacin and trimethoprim was tested, and some results gave a higher effect compared to the antibacterial. It is possible to use these synergies for skin infections, and we conclude that the anti-fungal has an effect on the bacteria when it is mixed with other antibiotics.