Unveiling the impact of interferon genes on the immune microenvironment of triple-negative breast cancer: identification of therapeutic targets
This study established a prognostic signature and a ceRNA network associated with interferon in TNBC, and identified five key regulatory axes. In the prognostic signature and the ceRNA axes, STXBP1, RBPMS-AS1, and FAM198B-AS1 were first reported as potential biomarkers of TNBC. These findings have the potential to provide new insights into the mechanisms driving TNBC tumorigenesis and development.
Authors
- Aamir Fahira (ORCID: https://orcid.org/0000-0001-5501-6884)
- Defang Ouyang (ORCID: https://orcid.org/0000-0002-8052-4773)
- Zunnan Huang (ORCID: https://orcid.org/0000-0002-5821-703X)
- Kai Zhuang (ORCID: https://orcid.org/0000-0003-1724-6210)
- Ying Liu (ORCID: https://orcid.org/0000-0001-9385-992X)
- Zhang Zhi (ORCID: https://orcid.org/0000-0002-8021-5604)
- Jiaojiao Wang (ORCID: https://orcid.org/0000-0002-6624-8717)
- Yong Liu (ORCID: https://orcid.org/0000-0001-6697-5052)
- Yan Lin (ORCID: https://orcid.org/0000-0003-1017-9211)
- Jiayi Cai (ORCID: https://orcid.org/0009-0002-3285-2761)
Institutions
- Guangdong Medical College (CN)
- Guangdong Pharmaceutical University (CN)
- University of Macau (MO)
- Songshan Lake Materials Laboratory (CN)
- Dongguan People’s Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioinformatics
- Published
- 2025-10-08
- DOI
- https://doi.org/10.3389/fbinf.2025.1629526
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00