Association between chronic kidney disease and sarcopenia: a national cohort study and two-step Mendelian randomization analysis
CKD is an independent risk factor for sarcopenia, with a clear temporal association. Mendelian randomization studies confirm this link and identify sedentary behavior and physical activity as mediators. These results underscore the need for early screening and individualized intervention strategies in CKD patients to prevent sarcopenia.
Authors
- Lihai Zhang (ORCID: https://orcid.org/0000-0002-1282-992X)
- Chen Chen (ORCID: https://orcid.org/0000-0003-3718-7588)
- Gongzi Zhang
- Hongji Wang
- Ying Zhou (ORCID: https://orcid.org/0000-0003-0645-0742)
Institutions
- Chinese PLA General Hospital (CN)
- People's Liberation Army 401 Hospital (CN)
- China Medical University (CN)
Publication Details
- Journal
- Archives of Gerontology and Geriatrics
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1016/j.archger.2025.106051
- Citations
- 1
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 1.16