Performance of GFAP and UCH-L1 compared to S100B in detecting intracranial injury: influence of age, hemolysis, neurodegenerative diseases, and extracranial fractures in a prospective cohort of over 1,000 patients
S100B and the GFAP/UCH-L1 combination demonstrated very high sensitivities, close to 100 %, with specificities of approximately 30 % for the diagnosis of intracranial lesions. Age-adjusted thresholds improve specificity in older patients, supporting their clinical implementation. This study also provides the first evidence that hemolysis significantly elevates UCH-L1 concentrations from 400 mg/L of hemoglobin.
Authors
- Charlotte Oris (ORCID: https://orcid.org/0000-0002-7360-4142)
- Damien Bouvier (ORCID: https://orcid.org/0000-0002-2707-4320)
- Antoine Puravet
- Jean‐Baptiste Bouillon‐Minois (ORCID: https://orcid.org/0000-0002-6556-4187)
- Jeannot Schmidt (ORCID: https://orcid.org/0000-0003-3424-337X)
- Vincent Sapin (ORCID: https://orcid.org/0000-0002-7452-315X)
- Farès Moustafa (ORCID: https://orcid.org/0000-0003-0949-1558)
- Julie Durif (ORCID: https://orcid.org/0000-0002-4237-9122)
- Bruno Pereira (ORCID: https://orcid.org/0000-0003-4955-1770)
- Benjamin Bouthors
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- University of Clermont Auvergne (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Clermont Université (FR)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1515/cclm-2025-1129
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00