Incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in North Carolina from December 2020 – February 2022
Nearly all participants had anti-SARS-CoV-2 antibodies by the end of follow-up, primarily through vaccination. The incidence of PCR-detected infections was similar to antibody testing, but PCR test positivity substantially underestimated incident infections. These findings emphasize the importance of prospective infection monitoring via antibody testing in a comprehensive approach to tracking viral infections in the community setting.
Authors
- Bonnie E. Shook‐Sa (ORCID: https://orcid.org/0000-0001-9506-4047)
- Caitlin A. Cassidy (ORCID: https://orcid.org/0000-0002-8796-4990)
- Christopher W. Woods (ORCID: https://orcid.org/0000-0001-7240-2453)
- C. Suzanne Lea (ORCID: https://orcid.org/0000-0001-8183-6528)
- Allison E. Aiello (ORCID: https://orcid.org/0000-0001-7029-2537)
- Aaron M. Kipp (ORCID: https://orcid.org/0000-0003-2651-2445)
- Richard Sloane
- Anne P. Starling (ORCID: https://orcid.org/0000-0002-6638-8314)
- L. Kristin Newby (ORCID: https://orcid.org/0000-0002-6394-8187)
- Annika K. Gunderson (ORCID: https://orcid.org/0000-0003-3536-3672)
- Ross M. Boyce (ORCID: https://orcid.org/0000-0002-9489-6324)
- David Wambui (ORCID: https://orcid.org/0000-0002-0320-0978)
- Aaron T. Fleischauer
- Coralei E. Neighbors (ORCID: https://orcid.org/0000-0002-0367-2983)
- Elyse M. Miller (ORCID: https://orcid.org/0000-0001-5548-4450)
- Douglas Wixted (ORCID: https://orcid.org/0000-0002-6128-7813)
Institutions
- University of North Carolina at Chapel Hill (US)
- Centers for Disease Control and Prevention (US)
- Duke University (US)
- East Carolina University (US)
- Clinical Research Institute (US)
- The Centers (US)
- Duke Medical Center (US)
- Center for Global Health (US)
- Duke University Hospital (US)
- Columbia University (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1371/journal.pone.0332645
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00