Trends in incidence, mortality and disability-adjusted life years of colorectal cancer in East Asia (1990–2021): An analysis of the Global Burden of Disease study 2021

Joinpoint analysis (1990-2021) demonstrated increases in CRC incidence (predominantly males) and declines in mortality/DALY rates (especially females) across most East Asian countries; however, substantial changes (non-overlapping UIs) were limited to few groups, warranting cautious interpretation. Despite progress, the persistent overall burden remains substantial, mainly driven by ageing and population growth. These findings underscore the need for country- and sex-specific prevention, screening, and lifestyle strategies.