Slight acceleration in podocyte mRNA loss in preterm-born children aged 3–5 years
This study is the first to confirm accelerated podocyte loss in the urine of 3-5-year-old preterm children. Although less severe than in the early postnatal period, it remains higher than in full-term children, providing crucial evidence for the involvement of podocyte depletion in the pathogenesis of preterm-related CKD. It also underscores the need for careful evaluation of the benefits and risks associated with antenatal corticosteroid use.
Authors
- Junling Ma
- Ying Chang (ORCID: https://orcid.org/0000-0002-5925-9821)
- Xueou Liu (ORCID: https://orcid.org/0000-0003-4974-2382)
- Fangrui Ding (ORCID: https://orcid.org/0000-0003-2206-6548)
- Li Kong (ORCID: https://orcid.org/0000-0002-3415-0520)
- Lulu Zhang (ORCID: https://orcid.org/0000-0003-2032-6879)
- Chao Ning (ORCID: https://orcid.org/0000-0001-8247-1700)
- Zhaoqiang Cui (ORCID: https://orcid.org/0000-0002-1150-1009)
Institutions
- Central South University (CN)
- Nankai University (CN)
- Tianjin Economic-Technological Development Area (CN)
- Tianjin Nankai Hospital (CN)
- Tianjin Central Hospital of Gynecology Obstetrics (CN)
Publication Details
- Journal
- Pediatric Nephrology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1007/s00467-025-06983-z
- Primary Topic
- Pediatric Urology and Nephrology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00