Six Interferon-Stimulated Genes as Biomarkers of M1 Macrophage Polarization in Psoriasis
Our findings suggest that six interferon-responsive genes (ISG15, RSAD2, IFIT3, OASL, GBP1, and IFIT1) could serve as potential biomarkers for M1 macrophage polarization in psoriasis. Targeting macrophage polarization through IFN pathway inhibition may offer novel therapeutic strategies, particularly for patients with prominent IFN signatures refractory to conventional treatments.
Authors
- Chuang Xiao (ORCID: https://orcid.org/0000-0002-6992-8283)
- Chen Chen (ORCID: https://orcid.org/0000-0003-0176-5112)
- Dan Xu (ORCID: https://orcid.org/0000-0003-0548-3833)
- Xing Liu (ORCID: https://orcid.org/0000-0002-3255-5399)
- Weiming Yang
- Guolan Ma
- Haixia Ji (ORCID: https://orcid.org/0000-0002-7687-982X)
- Sha Wu (ORCID: https://orcid.org/0000-0002-5372-7102)
- Lidan Hu (ORCID: https://orcid.org/0009-0007-2598-9838)
- Yan Mao
Institutions
- Yunnan University (CN)
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Yan'an Hospital Affiliated To Kunming Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s549922
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00