Genome‐wide association analysis identifies fucosyltransferase 2 variants associated with pancreatic intraductal papillary mucinous neoplasms
FUT2 variants are associated with the development of pancreatic IPMNs. FUT2 and rs601338 have important functions in mucin synthesis, biliopancreatic duct homeostasis, carcinoembryonic antigen, and cancer antigen 19-9 regulation, which provide a biologically plausible role in IPMN pathogenesis.
Authors
- Andrew L. Warshaw (ORCID: https://orcid.org/0000-0001-7788-3110)
- David Tsai Ting (ORCID: https://orcid.org/0000-0002-3261-2322)
- Peter J. Fagenholz (ORCID: https://orcid.org/0000-0002-7787-0317)
- Carlos F. Fernandez-del Castillo (ORCID: https://orcid.org/0000-0001-5975-7225)
- William R. Brugge (ORCID: https://orcid.org/0000-0001-9119-5170)
- Motaz Qadan (ORCID: https://orcid.org/0000-0001-6951-8308)
- Alison Patricia Klein (ORCID: https://orcid.org/0000-0003-2737-8399)
- Avinash Kambadakone (ORCID: https://orcid.org/0000-0001-6714-9190)
- Keith D. Lillemoe (ORCID: https://orcid.org/0000-0003-4283-8437)
- Brenna Casey (ORCID: https://orcid.org/0000-0001-6426-0838)
- Mari A. Mino-Kenudson (ORCID: https://orcid.org/0000-0002-9092-2265)
- Apostolos Gaitanidis (ORCID: https://orcid.org/0000-0003-3045-5252)
- Yasmin G. Hernandez‐Barco (ORCID: https://orcid.org/0000-0003-1266-3218)
- Shravya Srinivas Rao (ORCID: https://orcid.org/0000-0002-6864-9493)
Institutions
- Harvard University (US)
- Johns Hopkins University (US)
- Massachusetts General Hospital (US)
- Center for Cancer Research (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- Cancer
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1002/cncr.70114
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00