Engineering CRISPR System‐Based Bacterial Outer Membrane Vesicle Potentiates T Cell Immunity for Enhanced Cancer Immunotherapy (Adv. Mater. 39/2025)
Cancer Immunotherapy In article number 2501565, Xu Chen, Yihang Pan, Tianxin Lin, and co-workers have established a platform utilizing a CRISPR system-based bacterial outer membrane vesicle (OMV) for the efficient and cost-effective targeted delivery of plasmids. The intravesical administration of these engineered OMVs, which encoding CXCL-9 and IL-12, have been shown to effectively facilitating T-cell infiltration and activation. This process enhances the anti-tumor efficacy of OMV-mediated therapies and increases sensitivity to anti-PD-1/PD-L1 treatments. Consequently, this approach presents a novel strategy to address resistance to immunotherapy in the context of bladder cancer.
Authors
- Xiao Zhao (ORCID: https://orcid.org/0000-0002-4504-5670)
- Siting Chen (ORCID: https://orcid.org/0000-0003-3468-9320)
- Shengmeng Peng (ORCID: https://orcid.org/0009-0004-8989-9215)
- Junlin Lu (ORCID: https://orcid.org/0000-0002-3438-0297)
- Bailin Pan (ORCID: https://orcid.org/0000-0002-2563-8997)
- Xuwei Hong
- Hongjin Wang (ORCID: https://orcid.org/0009-0008-8649-7535)
- Xinrou Lin (ORCID: https://orcid.org/0000-0003-4859-9553)
- Changhao Chen (ORCID: https://orcid.org/0000-0002-9924-9054)
- Jianmei Zhong
- Hengji Zhan (ORCID: https://orcid.org/0000-0001-8574-9106)
- Leli Zeng (ORCID: https://orcid.org/0000-0002-3378-5241)
- Wenlong Zhong
- Ye Li (ORCID: https://orcid.org/0000-0002-8150-5056)
- Qiang Zhang (ORCID: https://orcid.org/0000-0003-3776-9799)
- Xu Chen (ORCID: https://orcid.org/0000-0002-8425-036X)
- Zehua Chen (ORCID: https://orcid.org/0000-0002-1204-679X)
- Yihang Pan (ORCID: https://orcid.org/0000-0002-4133-3691)
- Jiajian Lai
- Tianxin Lin
- Shaoxu Wu
- Sen Liu
- Kaiwen Jie
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Shantou Central Hospital (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Advanced Materials
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/adma.70627
- Citations
- 1
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.23