Catalyst‐Free Green Synthesis and Biological Study of Novel Cyclopentapyrrols Employing Multicomponent Reactions of Meldrum's Acid

ABSTRACT A novel multicomponent reaction strategy was employed to achieve high‐yield synthesis of new cyclopentapyrrol derivatives. The methodology involved the use of vinilydene Meldrum's acid, ethyl 2‐amino‐4‐dioxo‐4‐arylbutanoates, alkyl bromides and primary amines. The reaction was carried out at the reaction temperature in an aqueous medium. The antioxidant properties of the newly synthesized compounds are attributed to the presence of the NH functional group, and were confirmed through two standard evaluation methods. The antibacterial activity of the synthesized cyclopentapyrrols was assessed using the disc diffusion technique against two Gram‐negative bacterial strains. Additionally, these compounds demonstrated inhibitory effects against Gram‐positive bacteria. This synthetic approach offers several advantages, including high product yields, short reaction times, and straightforward product isolation procedures.