Continuous Subcutaneous Insulin Infusion (<scp>CSII</scp>)‐Associated Granulomatous Suppurative Reaction in Four Children With Type 1 Diabetes

With the increasing use of continuous glucose monitors and continuous subcutaneous insulin infusion (CSII) devices in pediatric patients with type 1 diabetes (T1DM), dermatologic complications are being reported more frequently. We describe four children with T1DM who developed persistent erythematous nodules with suppurative granulomatous inflammation at prior CSII injection sites. Treatment responses varied: one child improved after transitioning to subcutaneous insulin injections, another with oral dapsone, a third after switching CSII devices and limiting placement to the abdomen, and a fourth with topical corticosteroids and antibiotic ointment. This rare complication appears unrelated to specific device models or insulin types, highlighting the need for further studies to identify risk factors and guide optimal management.

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Journal
Pediatric Dermatology
Published
2025-10-08
DOI
https://doi.org/10.1111/pde.70030
Primary Topic
Skin Diseases and Diabetes
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article

Continuous Subcutaneous Insulin Infusion (CSII)‐Associated Granulomatous Suppurative Reaction in Four Children With Type 1 Diabetes

Tina Ho, Anna Cristina Garza‐Mayers, Sarah Lee, Valerie M. Carlberg et al.
Pediatric Dermatology
Skin Diseases and Diabetes
article

Continuous Subcutaneous Insulin Infusion (CSII)‐Associated Granulomatous Suppurative Reaction in Four Children With Type 1 Diabetes

Tina Ho, Anna Cristina Garza‐Mayers, Sarah Lee, Valerie M. Carlberg, Birgitta Schmidt, Patricia Todd
article en

Abstract

With the increasing use of continuous glucose monitors and continuous subcutaneous insulin infusion (CSII) devices in pediatric patients with type 1 diabetes (T1DM), dermatologic complications are being reported more frequently. We describe four children with T1DM who developed persistent erythematous nodules with suppurative granulomatous inflammation at prior CSII injection sites. Treatment responses varied: one child improved after transitioning to subcutaneous insulin injections, another with oral dapsone, a third after switching CSII devices and limiting placement to the abdomen, and a fourth with topical corticosteroids and antibiotic ointment. This rare complication appears unrelated to specific device models or insulin types, highlighting the need for further studies to identify risk factors and guide optimal management.

Pediatric Dermatology
Children's Hospital of Wisconsin (US), Boston Children's Hospital (US), Seattle Children's Hospital (US), Harvard University (US), Medical College of Wisconsin (US), Kosair Children's Hospital (US), Boston Children's Museum (US)
Openalex Percentile: Top 52%
Skin Diseases and Diabetes
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