Apigenin Suppresses NLRP3 Inflammasome Activation and Pyroptosis and Promotes Functional Recovery by Promoting Mitophagy in Experimental Spinal Cord Injured Rats
API attenuates microglial pyroptosis and facilitates SCI repair by enhancing mitophagy-mediated clearance of damaged mitochondria and suppressing activation of the ROS/NLRP3 inflammasome pathway in rats. These findings provide important preclinical evidence supporting the development of multi-target neuroprotective strategies derived from natural compounds.
Authors
- Yue Qin
- Cailiang Shen (ORCID: https://orcid.org/0000-0002-9835-6384)
- Yixiang Dong
- Zuomeng Wu
- Yaping Fang
- Tianyu Han (ORCID: https://orcid.org/0009-0002-3822-9022)
- Peiwen Song (ORCID: https://orcid.org/0000-0001-7423-3729)
- Ao Liu (ORCID: https://orcid.org/0009-0008-0176-3241)
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s549251
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81