Age and Spinal Level as Predictors of Lumbar Disc Degeneration in Humans and Mice: A Comparative Analysis
Age and spinal IVD level influence lumbar IVD degeneration in both human and mice with a higher rate of degeneration at the lumbosacral junction in both species. These findings suggest that mice are a suitable model for studying the cellular and molecular basis of IVD degeneration and associated neurological symptoms, with the L6-S1 level being the most relevant.
Authors
- Veeraj Shah (ORCID: https://orcid.org/0009-0005-1935-0566)
- Eric Bogner (ORCID: https://orcid.org/0000-0002-7543-9793)
- Tom Ross
- Matthew E. Cunningham (ORCID: https://orcid.org/0000-0003-3723-062X)
- Todd J. Albert (ORCID: https://orcid.org/0000-0002-4287-1512)
- Tejbir S. Pannu (ORCID: https://orcid.org/0000-0002-6052-0089)
- Russel C. Huang (ORCID: https://orcid.org/0000-0002-3977-9985)
- Chitra Lekha Dahia (ORCID: https://orcid.org/0000-0003-3683-9791)
- Ravij Mehta (ORCID: https://orcid.org/0000-0001-9645-8929)
- Darren R. Lebl (ORCID: https://orcid.org/0000-0003-2890-5795)
- Mathieu Bannwarth (ORCID: https://orcid.org/0000-0002-9187-9115)
- Bernard A. Rawlins
- Sohrab Virk (ORCID: https://orcid.org/0000-0001-9617-1987)
- Sheeraz A. Qureshi (ORCID: https://orcid.org/0000-0002-7177-1756)
- Han Jo Kim (ORCID: https://orcid.org/0000-0001-7880-690X)
- Harvinder S. Sandhu (ORCID: https://orcid.org/0000-0003-2013-1828)
- James C. Farmer
- Sarthak Mohanty
- Andrew Parker Hallmark
Institutions
- Hospital for Special Surgery (US)
- Cornell University (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-10-07
- DOI
- https://doi.org/10.1002/jsp2.70122
- Citations
- 1
- Primary Topic
- Musculoskeletal pain and rehabilitation
- Type
- article
- Field-Weighted Citation Impact
- 1.39