Enhancing Quercetin’s Potential: A Nanoliposome Delivery System for High Altitude Pulmonary Edema
QU reduces lung water content by modulating the PI3K/AKT/VEGF and ROCK/HIF/TRPC signaling pathways, suggesting its potential for preventing and treating HAPE. Furthermore, quercetin-loaded lipid nanoparticles improve oral bioavailability, thereby enhancing the therapeutic efficacy of quercetin in HAPE management.
Authors
- B. G. Shen (ORCID: https://orcid.org/0009-0005-8434-7996)
- Yao Gao (ORCID: https://orcid.org/0000-0001-8308-4729)
- Yue Gao (ORCID: https://orcid.org/0000-0003-1131-5326)
- Jialu Cui
- Xin Shen (ORCID: https://orcid.org/0000-0001-6766-001X)
- Chengrong Xiao
- Libin Wang (ORCID: https://orcid.org/0000-0002-1216-2352)
- Chengcai Lai (ORCID: https://orcid.org/0000-0002-4962-9892)
- Lin Lin (ORCID: https://orcid.org/0000-0002-2752-6251)
- Tingyu Yang (ORCID: https://orcid.org/0000-0003-4029-0404)
- Xianglin Tang
- Jiading Weng
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Guangdong Pharmaceutical University (CN)
- Chinese PLA General Hospital (CN)
- Beijing Radiation Center (CN)
- Shaanxi Polytechnic University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/dddt.s509270
- Primary Topic
- High Altitude and Hypoxia
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China