Reperfusion-dependent treatment effects of thrombectomy in patients with large ischemic infarcts

In this post hoc analysis of the TENSION trial, unsuccessful EVT did not worsen outcomes compared to BMT alone. The highest benefit of EVT occurred with first-pass complete reperfusion, emphasizing the importance of achieving optimal reperfusion in this vulnerable stroke subgroup. These findings do not justify general treatment recommendations.

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Publication Details

Journal
International Journal of Stroke
Published
2025-10-07
DOI
https://doi.org/10.1177/17474930251387613
Primary Topic
Acute Ischemic Stroke Management
Type
article
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article

Reperfusion-dependent treatment effects of thrombectomy in patients with large ischemic infarcts

Christian J. Thaler, Panagiotis Papanagiotou, Jan Raupach, Volker Puetz et al.
International Journal of Stroke
Acute Ischemic Stroke Management
article

Reperfusion-dependent treatment effects of thrombectomy in patients with large ischemic infarcts

Christian J. Thaler, Panagiotis Papanagiotou, Jan Raupach, Volker Puetz, Andreas Kastrup, Susanne Gellißen, Götz Thomalla, Dominik F. Vollherbst, Elke R. Gizewski, Martin Bendszus, Gabor C. Petzold, Markus Alfred Möhlenbruch, Anne Hege Aamodt, Helge C. Kniep, Fabien Subtil, Gernot Reimann, Silke Hopf-Jensen, Bastian Cheng, Bjørn Tennøe, Maximilian Schell, Jozef Haring, Blanca Fuentes, Antonı́n Krajina, Fabian Flottmann, Märit Jensen, Lukas Meyer, Nico Münnich, Egon Kurča, Rolf Ankerlund Blauenfeldt, Stefan Müller‐Hülsbeck, Peter A. Ringleb, Susanne Bonekamp, Christian Herweh, Ronni Mikkelsen, Kateřina Vališ, Vi Tuan Hua, Andrej Klepanec, Christian Ulfert, Laurent Pierot, Fee Christiane Keil, Gabriel Broocks, Matthias Bechstein, Paolo Pagano, Jens Fiehler, Eckhard Schlemm, Wolfgang Wick, Mayank Goyal, Silvia Schönenberger, Kamil Zeleňák, Hannes Deutschmann, Johannes Gerber, Mirko Pham, Michael D. Hill, Franziska Dorn, Claus Z. Simonsen, Eva Vítková, Angélique Denis
article en

Abstract

In this post hoc analysis of the TENSION trial, unsuccessful EVT did not worsen outcomes compared to BMT alone. The highest benefit of EVT occurred with first-pass complete reperfusion, emphasizing the importance of achieving optimal reperfusion in this vulnerable stroke subgroup. These findings do not justify general treatment recommendations.

International Journal of Stroke
Université Claude Bernard Lyon 1 (FR), Goethe University Frankfurt (DE), Oslo University Hospital (NO), Innsbruck Medical University (AT), University of Trnava (SK), Witten/Herdecke University (DE), Universität Hamburg (DE), Universität Innsbruck (AT), National and Kapodistrian University of Athens (GR), Medical University of Graz (AT), Norwegian University of Science and Technology (NO), Charles University (CZ), Masaryk University (CZ), Heidelberg University (DE), University Hospital Bonn (DE), Hospital Universitario La Paz (ES), German Center for Neurodegenerative Diseases (DE), University Hospital Heidelberg (DE), Aarhus University Hospital (DK), Foothills Medical Centre (CA), MSH Medical School Hamburg – University of Applied Sciences and Medical University (DE), DIAKO (DE), Hospices Civils de Lyon (FR), Helios Hospital Schwerin (DE), Centre Hospitalier Universitaire de Reims (FR), University Medical Center Hamburg-Eppendorf (DE), Universitätsklinikum Würzburg (DE), Amedes MVZ Hamburg (DE), Klinikum Dortmund (DE), University Hospital Frankfurt (DE), Laboratoire de Biométrie et Biologie Evolutive (FR), Klinik und Poliklinik für Neurologie (DE), Klinikum Bremen-Mitte (DE), University Hospital Carl Gustav Carus (DE), Klinik und Poliklinik für Psychotherapie und Psychosomatik (DE), Hôpital Maison Blanche (FR), Chirurgische Universitätsklinik Heidelberg (DE), Comenius University Bratislava (SK), Université de Reims Champagne-Ardenne (FR)
Openalex Percentile: Top 62%
Acute Ischemic Stroke Management
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